Port St. Lucie, FL

Large Dogs for Adoption in Port St. Lucie, FL: 16 Big Dogs Looking for a Home

Large Dogs up for adoption near Port St. Lucie, FL

Rescues and shelters within 100 miles of Port St. Lucie have 16 large dogs up for adoption. Here are all 16, each with photos, their story and how to reach the rescue looking after them.

Big dogs often wait longer for homes than small ones, though many are gentle, loyal and easy-going. Every dog on this page is listed by their rescue as large or extra large, with breeds like Pit Bull Terrier, Labrador Retriever and Husky.

1. Gator

Puppy (3 months 2 days) · Male · Pit Bull Terrier (short coat) · 74 mi from Port St. Lucie

Ally and Gator were rescued together from a crate left outside. They were able to be brought to safety and a temporary foster has stepped up to help them transition and get the medical care they need to find their forever home. Please fill out an application for Gator. He is a sweet and playful puppy that will thrive in an active family home.

The cutest part of him is not just the brindle coat, but his little panda face markings on his nose.

  • Good with kids
  • Good with dogs
Adopt Gator fromEverglades Angels Dog RescuePompano Beach , FL · listed Oct 20

2. Ally

Puppy (3 months 2 days) · Female · Pit Bull Terrier (short coat) · 74 mi from Port St. Lucie

Ally and her brother Gator had been rescued from outdoor crates left outside to suffer alone. As luck would have it, we were able to make room for them.

Ally is a sweet and playful pup that would be happy to grow up in a family home.

  • Good with kids
  • Good with dogs
Adopt Ally fromEverglades Angels Dog RescuePompano Beach , FL · listed Oct 20

3. Ragnar

Adult (3 years 9 months) · Male · Labrador Retriever · 41 mi from Port St. Lucie

I am being rehomed because both my parents are first responders and they want me to have more attention than what I get now. They're hoping I have a big house and a fenced yard to play in. I am housebroken and crate trained. I don't have to be crated when they're not home. I live with two other dogs that are much older. I'm great with kids. I'm a little scared of cats.

  • Good with kids
  • Good with dogs
  • House-trained
Adopt Ragnar fromA Second Chance Puppies and Kittens RescueRoyal Palm Beach, FL · listed Oct 15

4. Handsome

Adult · Male · Husky / Terrier / Mixed (short coat) · 78 mi from Port St. Lucie

he is 1 year old and weight appx. 45 pounds. Our adoption center & Spay Clinic is open by appointment with approved application. We are located at 571 NE 44th Street, the NW corner of Prospect (44th) and 6th in Oakland Park, FL. Our application is available online: www.animal-aid.com where you can also view all of our adoptable dogs and cats. The $200 donation we are requesting will help the next dog or cat in need and includes our medical program; 5-way vaccines, rabies vaccine, de-worming, blood test for heartworm and tick diseases, spay or neuter and microchip ID.

  • Good with kids
  • Good with dogs
  • Good with cats
  • House-trained
Adopt Handsome fromAnimal Aid, Inc.Oakland Park, FL · listed Oct 15

5. Daisy

Young · Female · Great Dane · 25 mi from Port St. Lucie

Daisy is a 2 year old female she is very friendly great with other dogs,cars and kids. She came into our rescue in labor she is now a mama. She will be ready for her furever family on 11-14 if interested in adopting her get an application in to our rescue. Question call us at 561-748-4017.

  • Good with kids
  • Good with dogs
  • Good with cats
  • House-trained
Adopt Daisy fromGreat Dane Rescue of South FloridaPalm Beach, FL · listed Oct 15

6. Joanie

Young · Female · American Bulldog / American Staffordshire Terrier / Mixed · 100 mi from Port St. Lucie

Urgent

Could anyone use a Halloween buddy to watch spooky movies with?

Joanie would LOVE to be your Halloween movie buddy! ❤️ Imagine this sweet 85-lb girl curled up next to you while you watch scary movies, handing out treats, and enjoying Halloween together!

She’s
2 years old, spayed, microchipped, and up to date on vaccines and preventatives.
She’s affectionate, loving, housebroken, and absolutely loves people.

But Joanie’s time is running out — she is scheduled to be euthanized Tuesday.

Could YOU be the person who gives Joanie her happily-ever-after?
Please foster or adopt and SAVE HER LIFE! ❤️

JOANIE

  • Good with kids
  • Good with dogs
  • House-trained
Adopt Joanie fromHopeful Paws of FloridaEstero, Fl · listed Oct 12

7. Anna

Adult · Female · Vizsla / Mixed (short coat) · 49 mi from Port St. Lucie

You can apply for Anna at https://ladyluckanimalrescue.wufoo.com/forms/canine-adoption-agreement-and-application/ ❤️
Anna is an 8 year old Vizsla Mix Female who was recently owner surrendered to us by her odopter who felt she was too old for a dog of Anna’s size. Anna weighs approximately 55 lbs. She loves going on car rides to the park to play with other dogs and she enjoys the beach! Anna is wonderful in her foster home where there are currently two male large breed dogs. Her foster Dad works from home and has a large fenced in yard for her to play in. Anna’s ideal adopter will have dogs with similar energy (no cats) and will work from home or be retired.

Read more about Anna

Anna enjoys being surrounded by other dogs and her humans. She was abandoned and found as a stray, so being alone is scary for her! She’s affectionate, house trained, walks well on a leash and overall an easy keeper for the right person.
Anna is currently being fostered in Jupiter Florida. She’s ready to find her Forever home!

  • Good with kids
  • Good with dogs
  • No cats
  • House-trained
Adopt Anna fromLady Luck Animal Rescue, Inc.Lighthouse Point, FL · listed Sep 20

8. Lyssa

Young (2 years) · Female · German Shepherd Dog / Mixed · 81 mi from Port St. Lucie

She was abandoned in a Miami parking lot that had a large population of stray cats, and she remained there for several weeks. Several local rescuers saw a Nextdoor post about her and stepped in to help. They were able to safely trap her that same night and reached out to us once she was secure — and of course we said yes.

We believe Lyssa is around 2 years old. She is a calm, gentle girl who rides well in the car. She doesn’t seem bothered by other dogs, though she has not been officially dog‑tested yet.

Read more about Lyssa

Lyssa is currently located at our vet in West Palm Beach and is in need of a foster — or even better, an adopter who can give her the stable, loving home she deserves.

Adopt Lyssa fromShepherd Help and Rescue Effort, Inc.Plantation, FL · listed Sep 19

9. Farro

Puppy · Male · Mastiff / Labrador Retriever / Mixed (short coat) · 78 mi from Port St. Lucie

He is appx. 6 months old and weighs 25 pounds. he is expected to be over 60lbs when grown. Our adoption center & Spay Clinic is open by appointment with approved application. We are located at 571 NE 44th Street, the NW corner of Prospect (44th) and 6th in Oakland Park, FL. Our application is available online: www.animal-aid.com where you can also view all of our adoptable dogs and cats. The $100 donation we are requesting will help the next dog or cat in need and includes our medical program; 5-way vaccines, rabies vaccine, de-worming, blood test for heartworm and tick diseases, spay or neuter and microchip ID.

  • Good with kids
  • Good with dogs
  • Good with cats
Adopt Farro fromAnimal Aid, Inc.Oakland Park, FL · listed Aug 24

10. Jack

Senior · Male · Plott Hound / Mixed · 97 mi from Port St. Lucie

Meet Jack, a sweet 11-year-young gentleman with the biggest heart.
Jack is truly an oldie but a goodie, but don’t let his age fool you—he’s still got plenty of pep in his step! He enjoys the simple things in life, whether that’s soaking up the sunshine during a cozy nap or heading out on a new adventure.
Jack is quiet, easygoing, and non-reactive. He loves people watching from the porch and taking in everything happening around him. And when his playful side comes out, it’s absolutely adorable! You’ll find him rolling around in the grass, running at the start of his walks, or even chasing waves at the beach.
Jack is so easy to be around, and all he really wants is someone to share his golden years with. If you’re looking for a loving, laid-back companion with just the right amount of playful spirit, Jack might be your perfect match.
Come on! Submit an application and come meet this senior sweetie today!
https://animalrefugecenter.com/adoption-application

Read more about Jack

My ideal home:
I just need a loving family to cuddle up with
I'm good with:

Some Other Dogs
Young Children
Older Children
Men
Women

Date of birth Oct 2015

  • Good with kids
  • Good with dogs
  • No cats
Adopt Jack fromAnimal Refuge CenterNorth Fort Myers, FL · listed Aug 17

11. Roy

Adult (8 years 3 months) · Male · Pit Bull Terrier / Mixed (short coat) · 74 mi from Port St. Lucie

Rex & Roy — Twice the Love, One Very Special Bond ❤️

Some dogs find their person.

Rex and Roy found each other.

These two sweet boys are a truly bonded pair, and after six months in our care, we can say with confidence that they are every bit as special as they look in their photos.

Rex

, a 4-year-old Pit mix, and

Roy

, an 8-year-old Husky mix, are affectionate, lovable companions who share an incredible friendship. They are happiest together, whether they’re relaxing side by side, enjoying attention, or simply keeping each other company.

Read more about Roy

Roy is the older, laid-back gentleman of the pair, while Rex brings a little younger energy to the partnership. Together, they balance each other beautifully.

They have become very loved members of the Everglades Angels family, but what they need now is something we cannot give them at the rescue:

a home and family of their own.

We know adopting two large dogs is a bigger commitment, but Rex and Roy come with something pretty wonderful — they already have a best friend built in. You won’t just be adopting two dogs. You’ll be giving two devoted friends the happy ending they have been waiting for.

After six months of waiting, we would love nothing more than to see these sweet boys walking out our doors

together, forever.

Adoption Requirement:

Rex & Roy must be adopted together.

If you have room in your home — and your heart — for two wonderful boys,

please give Rex and Roy a chance. They have waited long enough for someone to choose them

Rex

DOB: February 2022

Breed: Pit mix

Weight: 74 lbs

Roy

DOB: February 2018

Breed: Husky mix

Weight: 85 lbs

Rescue Date:

February 15, 2026

  • House-trained
Adopt Roy fromEverglades Angels Dog RescuePompano Beach , FL · listed Aug 17

12. Melanie Rose

Senior (8 years 2 months) · Female · Pit Bull Terrier (short coat) · 74 mi from Port St. Lucie

Melanie Rose was found abandoned at a church in Pembroke Pines, FL.

I am 8 years old, which means I have a lot of love stored up and I am very ready to give all of it to you. I love walks - genuinely, enthusiastically, every single time. I love stuffed animals and I take very good care of them. I love cuddles more than almost anything in the world and I am exceptionally good at them. I am told I am the biggest cuddle bug anyone here has ever met and I accept that title with full sincerity.

Read more about Melanie Rose

I am potty trained and great in the car and fine on my own when I need to be. I have done a lot of hard things and I have handled all of them with more grace than anyone had a right to expect.

All I need now is you. A patient home. A soft couch. Someone who understands that 8 years old is not too old - it is just the right age to finally get everything I deserve.

  • No cats
Adopt Melanie Rose fromEverglades Angels Dog RescuePompano Beach , FL · listed Jul 16

13. Leia

Young · Female · German Shepherd Dog / Mixed · 97 mi from Port St. Lucie

This beautiful girl came to ARC from LaBelle Animal Control with her best friend, Red, and she’s been winning hearts ever since. Blue has a fun-loving personality and an endless supply of happy tail wags. She loves to play, enjoys spending time with people, and is always ready to make a new friend.
With her sweet nature and cheerful spirit, Blue brings joy wherever she goes. Whether it’s a walk, a game of fetch, or simply soaking up affection, she’s happiest when she’s with her favorite humans.
Blue is ready to find a family to call her own and fill their home with love, laughter, and plenty of wiggly excitement.

Read more about Leia

Submit an application and schedule an appointment to meet this special girl—you just might find your new best friend!
https://animalrefugecenter.com/adoption-application
My ideal home:I need a family to give me lots of lovI'm good with:Some Other Dogs Cats Young Children Older Children Men Women
Date of birth Nov 2025

  • Good with kids
  • Good with dogs
  • No cats
  • House-trained
Adopt Leia fromAnimal Refuge CenterNorth Fort Myers, FL · listed Jun 17

14. Morgan

Young (8 months) · Female · Terrier (short coat) · 74 mi from Port St. Lucie

How do you find a 5-month-old puppy wandering around with a rope tied around his neck? Sadly, someone did.

Thankfully, they stopped, picked him up, and brought her to us at Everglades Angels Dog Rescue.

Meet Morgan. She is just a baby with her whole life ahead of her. Instead of being safe, loved, and cared for, she was left to fend for herself. We may never know her story, but we do know how her next chapter will go.

Morgan is now safe.

Morgan is a wonderful and playful pup that has a tail wag for everyone and kisses galore!

Adopt Morgan fromEverglades Angels Dog RescuePompano Beach , FL · listed Jun 3

15. Riley

Young · Female · Husky (medium coat) · 8 mi from Port St. Lucie

Riley is a wonderful mix of playful energy and calm, loving companionship. She may have bursts of fun, happy energy, but she also knows how to settle down and soak up all the love. This sweet girl has a gentle, affectionate nature that makes her an absolute joy to be around.Riley gets along great with other dogs, is already house broken, and loves making her people happy. She’s treat-motivated and knows her basic commands, which makes her both smart and eager to please. She will need a fenced in yard or someone who can teach her how to walk on a leash. If you’re looking for a dog who can keep up with playtime and then happily relax by your side, Riley could be the perfect match for you.

  • Good with dogs
Adopt Riley fromRescue Adoption Inc.Fort Pierce, FL · listed May 25Courtesy listing: Riley's family is rehoming her through this rescue.

16. Asher

Young · Male · Labrador Retriever / Mixed (short coat) · 8 mi from Port St. Lucie

ASHER is a happy, affectionate, and playful boy, 1 year old ( 53 lbs).Asher loves getting outside to enjoy the fresh air, whether he’s exploring his surroundings or heading out for a nice walk. He’s also a big fan of belly rubs and soaking up quality time with staff and volunteers — attention is definitely one of his favorite things! He enjoys showing off the basic commands he’s learned, especially when yummy treats are involved.This smart young pup is also working toward being fully housebroken and continues to make steady progress with routine and consistency.
Asher is one of five littermates, and they have already found their forever homes.

Read more about Asher

He is still patiently waiting for his turn. Because of his playful energy, he would likely do best in a home with children 10 years or older. A high, secured, fenced‑in yard would be ideal for him to safely run and play, or he’d thrive with a family or individual who enjoys long walks and staying active.
Contact directly at:info@pawsfurrecovery.org772-446-1916
Apply today to make Asher part of your family:https://pawsfurrecovery.org/adoption-application/

  • Good with dogs
Adopt Asher fromRescue Adoption Inc.Fort Pierce, FL · listed May 21

Adopting a large dog in Port St. Lucie

Large dogs need room to stretch out and plenty of exercise: at least one good walk a day, and a secure yard is a bonus. Check your lease too, as some landlords limit the size or breed of dog.

Start training from day one. A big dog who walks nicely on a leash and doesn't jump up is a pleasure to live with, and many rescues can recommend a local trainer.

Rescues with large dogs near Port St. Lucie

Questions about adopting large dogs in Port St. Lucie

How many large dogs are up for adoption in Port St. Lucie?

As of November 4, 2026, rescues and shelters within 100 miles of Port St. Lucie, Florida, have 16 large dogs up for adoption. The list is updated every day.

Where can I adopt a large dog in Port St. Lucie?

The rescues with the most large dogs near Port St. Lucie right now are Everglades Angels Dog Rescue (Pompano Beach , FL), Animal Aid, Inc. (Oakland Park, FL) and Animal Refuge Center (North Fort Myers, FL). Each dog above has the rescue's phone number and website.

Can I adopt a large dog if I live in an apartment?

Often, yes. Many big dogs are calm indoors as long as they get enough walks and exercise. Check your lease for size or breed limits, and ask the rescue how active the dog is.

Listings are updated daily. Rescues are responsible for their own listings; a dog may have been adopted since this page was updated.